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CSIRO Postdoctoral Fellowship in Biosensor Technology for Cell and Tissue Culture

CSIRO

The Opportunity Do you have a PhD in 2D/3D human cell culture systems, biosensor technology, biomedical engineering or material science? An outstanding opportunity to pioneer the development of photonic biosensing technology Work with a diverse team of field experts in our Biomedical Manufacturing program in this exciting postdoctoral role CSIRO Early Research Career (CERC) Postdoctoral Fellowships provide opportunities to scientists and engineers who have completed their doctorate and have less than three years of relevant postdoctoral work experience. These fellowships aim to develop the next generation of future leaders of the innovation system. Scaled cGMP cell manufacturing needs new precision feedback and closed loop production processes to realise clinical efficacies and the sustainable cost of goods from cellular products.

Current cell culture systems remain hampered by an inability to interrogate, capture and respond in situ to real time bio-responses. This Postdoctoral Fellowship is an outstanding opportunity to pioneer the development of photonic biosensing technology that provides in situ detection and corrective feedbacks for markers of cell health. This platform technology will be developed in 2D and bioreactor human cell culture formats, paving the way for scaled precision cGMP cell therapeutic production systems.

The Postdoctoral Fellow will develop this smart technology platform and novel biosensing capability by working with diverse field experts in CSIRO’s Biomedical Manufacturing program and through collaboration with CSIRO’s Future Science Platforms, Monash University and internationally with the Max Plank and Weizmann Institutes. The project will access supervisory team capability in human 2D/3D culture formats and cell nutrient systems, biological tethering strategies and the fabrication of miniaturised photonic structures to support the research challenge. Your duties will include: I dentifying, then validating, a predictive in situ panel of key analyte/biomarkers relevant to the health of diverse human 2D/3D cell culture systems.

Designing, manufacturing and optimising polystyrene culture formats (2D and microcarriers) embedding photonic detection outputs suitable for selected biological analytes. Investigating optimised smart culture formats enabling early detection of key biomarkers. Investigating bioconjugation approaches for the responsive release of drugs and critical cell culture nutrients.

Establishing relevant industry collaboration links. Location: Clayton, Victoria Salary: AU$88k - AU$96k plus up to 15.4% superannuation Tenure: Specified term of 3 years Reference: 76121 To be considered you will need: A doctorate (or will shortly satisfy the requirements of a PhD) in a relevant discipline area, such as 2D/3D human cell culture systems, biosensor technology, biomedical engineering or material science.

Please note: To be eligible for this role you must have no more than 3 years (or part-time equivalent) of pos.

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Date14 September 2021

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